Tezepelumab, sold under the brand name Tezspire, is a human monoclonal antibody used for the treatment of asthma. Tezepelumab blocks thymic stromal lymphopoietin (TSLP), an epithelial cytokine that has been suggested to be critical in the initiation and persistence of airway inflammation. The most common side effects include arthralgia (joint pain) and pharyngitis (… Web1、自免领域:公司通过自主研发建立了il-4rα、tslp、masp-2等多个靶点构成的差异化自免组合,适用于广泛过敏患者群体。公司靶向il-4rα的cm310与靶向tslp的cm326 ... 从管线来看,核心产品moa ...
TSLP: from allergy to cancer Nature Immunology
WebTSLP stands for thymic stromal lymphopoietin. Some facts about TSLP include: It is a cytokine. A cytokine is a glycoprotein that regulates cellular responses. 3. Expressed by … Web★ 基于明确moa设计,便于药物机制研究; ★ 采用萤光素酶(luc)报告基因系统,反应信号强,灵敏度高; ★ 经过严格指控,确保足够的检测窗口, 适用不同药效筛选; ★ 经代次稳定性验证,可稳定传代>20代,利于方法学验证; ★ 售前免费样本测试,售后技术支持及兜底政策保障 ☛ 点击查看acro ... how many episodes of tng are there
Tezepelumab: Uses, Interactions, Mechanism of Action
WebNov 19, 2024 · TSLP (thymic stromal lymphopoietin) is a member of the four-helix-bundle cytokine family and is a distant paralog of the cytokine IL-7 1.As its full name suggests, … WebThymic stromal lymphopoietin (TSLP) is an IL-7–like cytokine expressed by epithelial cells and keratinocytes. Its receptor comprises TSLP receptor (TSLPR) and IL-7Rα, which is expressed primarily on monocytes and myeloid-derived DCs, as well as on B cells. TSLP-treated human DCs promote Th2 differentiation.35 A major means by which TSLP ... WebSep 7, 2024 · Thymic stromal lymphopoietin (TSLP) is an epithelial-cell–derived cytokine produced in response to environmental and … how many episodes of toh season 3