Cinnamic acid inhibition cancer cells
WebApr 1, 2024 · We synthetized seventeen cinnamates derived from trans -cinnamic acid. • The Steglich esterification reaction was the main step involved in their synthesis. • The most effective compound 3q reduced the melanoma cell viability. • Compound 3q caused cell cycle arrest and apoptosis in B16-F10 cells. • WebJul 28, 1995 · We now show that cinnamic acid induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. The concentration causing a 50% …
Cinnamic acid inhibition cancer cells
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WebCA treatment increased the levels of lipid peroxidation in Hela and ME-180 cells. Among all the concentrations (30, 40, and 50 μg/ml) tested, 50 μg of CA showed maximum levels of thio-barbituric acid reactive substances (TBARS), CD, and LHP in HeLa and ME-180 cells (Figure 73.5).Pro-oxidant activity of hydroxycinnamic acids on DNA damage and lipid … WebMar 23, 2016 · For the inhibition of cancer cell proliferation, the concentration of tCA reaching mM levels was required; however, the study data verified that tCA interfered in histone acetylation via inhibiting HDAC, leading to cancer cell cytotoxicity. In addition, the therapeutic efficacy of tCA has been confirmed. ... Cinnamic acid induces apoptotic cell ...
Webp-Coumaric acid (pCA) is a hydroxycinnamic acid derivative commonly found in many natural products that has been extensively studied for its anticancer activity in multiple … WebBackground: Berberine and cinnamic acid are natural compounds that exhibit potent anticancer activities through distinct molecular mechanisms. Objective: In the present study, we aimed to investigate the proapoptotic potential of cinnamic acid and berberine in cancer cells by examining their effect on the expression of proapoptotic and antiapoptotic genes.
WebMar 25, 2015 · Although one of the best characterized inhibitors, α-cyano-4-hydroxycinnamic acid (α-CCA), possesses a 10-fold selectivity for MCT1 compared to other subtypes (Figure 1) [22], it also shows ... WebCA can inhibit the growth of leukaemia cells by inducing cell apoptosis and significantly affected the cell cycle after 48 h treatment, resulting in increased G0/G1 phase and extension of thecell cycle in the tumour cells. This study aims to investigate the effect and mechanism of action of cinnamic acid (CA) on the proliferation and apoptosis of …
WebMar 10, 2024 · Two possible mechanisms were considered [ 17 ]: 1) CA activates the human peroxisome proliferator and nuclear receptor to inhibit oncogene (may be c-myc) amplification and expression of other genes; 2) CA blocks the posttranslational modification of cell growth-regulating proteins, such as certain p21ras protein, that is, preventing …
WebSep 9, 2024 · Results: Cinnamic acid inhibited cell viability and cell invasion, as well as decreased ECAR and OCR, in primary endometrial stromal cells. Cinnamic acid … eastman school of music jazz programWebApr 12, 2024 · Naproxen is widely used for anti-inflammatory treatment but it can lead to serious side effects. To improve the anti-inflammatory activity and safety, a novel naproxen derivative containing cinnamic acid (NDC) was synthesized and used in combination with resveratrol. The results showed that the combination of NDC and resveratrol at different … eastman school of music organ departmentWebSep 25, 2013 · Interestingly, cinnamic acid also exhibits anti-cancer activity in the cancer stem cells. Huang et al. (2012)examined the effect of cinnamic acid in lung cancer stem cells.... eastman school of music notable alumniWebNov 30, 2024 · A search for naturally occurring HDAC inhibitors continues due to the adverse effects associated with known HDAC inhibitors like SAHA and TSA. Therefore … eastman school of music ranking us newsWebDec 19, 2024 · Inflammation and oxidative stress are involved in cardiovascular diseases. Nitrogen monoxide participates in the regulation of endothelial processes. Thus, derivatives of classic nonsteroidal anti-inflammatory drugs (NSAIDs), trolox or cinnamic acids esterified with 2-(nitrooxy)ethanol were designed and studied. It was found that the nitrogen … eastmans fitnessWebOct 21, 2024 · Incubation of human colorectal cancer cells in the presence of cinnamic acid at concentration higher than 10 mM resulted in reduced cell viability (IC50 13.6 mM). ... The mechanism is attributed to the lower expression of some drug resistance proteins, inhibition of cell proliferation, and promotion of apoptosis (Lu et al. 2024). eastman serial numberWebJul 24, 2010 · Conclusion: Our study suggests that anti-tumor effect of cinnamon extracts is directly linked with enhanced pro-apoptotic activity and inhibition of NFkappaB and AP1 … eastman sharepoint